Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies

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Sánchez, Ricardo and Ayala Díaz, Rosa María and Martínez López, Joaquín (2019) Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies. International Journal of Molecular Sciences, 20 (11). p. 2832. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20112832




Abstract

Ultra-deep next-generation sequencing has emerged in recent years as an important diagnostic tool for the detection and follow-up of tumor burden in most of the known hematopoietic malignancies. Meticulous and high-throughput methods for the lowest possible quantified disease are needed to address the deficiencies of more classical techniques. Precision-based approaches will allow us to correctly stratify each patient based on the minimal residual disease (MRD) after a treatment cycle. In this review, we consider the most prominent ways to approach next-generation sequencing methodologies to follow-up MRD in hematological neoplasms.


Item Type:Article
Uncontrolled Keywords:minimal residual disease; next-generation sequencing; clonal evolution; hematological neoplasms; high-throughput sequencing
Subjects:Medical sciences > Medicine > Oncology
ID Code:65882
Deposited On:10 Jun 2021 14:31
Last Modified:10 Jun 2021 15:40

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