The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

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Lupu, Diana and Andersson, Patrik and Bornehag, Carl-Gustaf and Demeneix, Barbara and Fritsche, Ellen and Gennings, Chris and Lichtensteiger, Walter and Leist, Marcel and Leonards, Pim E. G. and Ponsonby, Anne-Louise and Scholze, Martin and Testa, Giuseppe and Fernández-Tresguerres Hernández, Jesús Ángel and Westerink, Remco H. S. and Zalc, Bernard and Rüegg, Joëlle (2020) The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. International Journal of Molecular Sciences, 21 (11). p. 3978. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms21113978




Abstract

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.


Item Type:Article
Uncontrolled Keywords:endocrine-disrupting chemicals; developmental neurotoxicity; chemical testing; adverse outcome pathways
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Medicine > Physiology
ID Code:65885
Deposited On:08 Jun 2021 16:06
Last Modified:23 Jun 2021 10:34

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