Heart Failure Is a Risk Factor for Suffering and Dying of Clostridium difficile Infection. Results of a 15-Year Nationwide Study in Spain

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Méndez Bailón, Manuel and Jiménez García, Rodrigo and Hernández-Barrera, Valentín and Miguel Díez, Javier de and Miguel Yanes, José María de and Muñoz-Rivas, Nuria and Lorenzo-Villalba, Noel and Carabantes Alarcón, David and Zamorano León, José Javier and Astasio Arbiza, Paloma and Ortega Molina, Paloma and López-de-Andrés, Ana (2020) Heart Failure Is a Risk Factor for Suffering and Dying of Clostridium difficile Infection. Results of a 15-Year Nationwide Study in Spain. Journal of Clinical Medicine, 9 (3). p. 614. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm9030614




Abstract

Background: We aimed to (1) analyze time trends in the incidence and in-hospital outcomes of heart failure (HF) patients suffering Clostridioides difficile infection (CDI); (2) compare clinical characteristics of CDI patients between those with HF and matched non-HF patients; and (3) identify predictors of in-hospital mortality (IHM) among HF patients suffering CDI. Methods: Retrospective study using the Spanish National Hospital Discharge Database from 2001 to 2015. Patients of age ≥40 years with CDI were included. For each HF patient, we selected a year, age, sex, and readmission status-matched non-HF patient. Results: We found 44,695 patients hospitalized with CDI (15.46% with HF). HF patients had a higher incidence of CDI (202.05 vs. 145.09 per 100,000 hospitalizations) than patients without HF (adjusted IRR 1.35; 95% CI 1.31–1.40). IHM was significantly higher in patients with HF when CDI was coded as primary (18.39% vs. 7.63%; p < 0.001) and secondary diagnosis (21.12% vs. 14.76%; p < 0.001). Among HF patient’s predictor of IHM were older age (OR 8.80; 95% CI 2.55–20.33 for ≥85 years old), those with more comorbidities (OR 1.68; 95% CI 1.12–2.53 for those with Charlson Comorbidity index ≥2), and in those with severe CDI (OR 6.19; 95% CI 3.80–10.02). Conclusions: This research showed that incidence of CDI was higher in HF than non-HF patients. HF is a risk factor for IHM after suffering CDI.


Item Type:Article
Uncontrolled Keywords:Clostridium difficile infection; heart failure; in-hospital mortality; hospitalization; incidence
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Public health
ID Code:65892
Deposited On:07 Jun 2021 14:49
Last Modified:08 Jun 2021 18:33

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