Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion

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Chamorro, Virginia and Pandolfi, Rachele and Moreno Gutiérrez, Laura and Barreira, Bianca and Martínez-Ramas, Andrea and Morales Cano, Daniel and Ruiz-Cabello, Jesús and Lorente, José and Duarte, Juan and Cogolludo Torralba, Ángel Luis and Álvarez-Sala Walther, Jose Luis and Pérez Vizcaíno, Francisco (2016) Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion. Molecules, 21 (12). p. 1739. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules21121739




Abstract

Background: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock.
Methods: Rats were anesthetized (80 mg/kg ketamine plus 8 mg/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were administered during resuscitation.
Results: There was a trend for increased survival 84.6% (11/13) in the treated group vs. the shock group 68.4% (13/19, p > 0.05 Kaplan–Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals.
Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion.


Item Type:Article
Uncontrolled Keywords:systemic arterial pressure; lung edema; hemorrhage; trauma; reperfusion
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Veterinary > Laboratory animals
ID Code:65898
Deposited On:03 Jun 2021 14:08
Last Modified:04 Jun 2021 06:48

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