Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study

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San Mauro Martín, Ismael and Garicano Vilar, Elena and Sanz Rojo, Sara and Collado Yurrita, Luis Rodolfo and Pérez Arruche, Eva and Arce Delgado, Esperanza and Blumenfeld Olivares, Javier Andrés (2019) Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study. Nutrients, 11 (10). p. 2538. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu11102538




Abstract

Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.


Item Type:Article
Uncontrolled Keywords:children; cholesterol; genetics; low-density lipoprotein cholesterol; sterol
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Medical microbiology
ID Code:65905
Deposited On:02 Jun 2021 14:34
Last Modified:03 Jun 2021 06:26

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