Publication: Desarrollo galénico de nuevos sistemas deliberación colónica de meloxicam
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2021-06-09
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Universidad Complutense de Madrid
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Abstract
El meloxicam (MLX) es un antiinflamatorio no esteroídico (AINE) de la familia Oxicam. Este grupo de AINEs se utiliza frecuentemente en el tratamiento de la artritis reumatoide y de inflamaciones postoperatorias. Es un buen antioxidante, y, recientemente, se le ha encontrado utilidad en la quimioprevención, quimiosupresión y protección UV.El MLX es un inhibidor selectivo de COX-2, con alta selectividad y menores efectos secundarios gastrointestinales. Ya que es un fármaco con buena absorción en la región colónica, se están estudiando sus propiedades contra el cáncer de colon y otras enfermedades de esta área, por lo que es interesante investigar nuevas formulaciones de administración colónica de MLX. En esta tesis se estudia el comportamiento de granulados sin y con un 5% de celulosa y con un tipo de Eudragit® (RS, FS o NM), y con mezclas de los polímeros RS + FS y NM +FS...
Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAID) of the Oxicamf amily. This group of NSAIDs is frequently used in the treatment of rheumatoid arthritis and postoperative inflammation. It is a good antioxidant, and recently it has been found useful in chemoprevention, chemosuppression, and UV protection.MLX is a selective COX-2 inhibitor, with high selectivity and fewer gastrointestinal side effects. Due to MLX is a drug with good absorption in the colonic region, its properties against colon cancer and other diseases in this area are being studied, so it is interesting to investigate new formulations for colonic administration of MLX. This thesis studies the behavior of granules without and with 5% cellulose and with a type of Eudragit® (RS, FS or NM), or with mixtures of the polymers RS + FS and NM + FS...
Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAID) of the Oxicamf amily. This group of NSAIDs is frequently used in the treatment of rheumatoid arthritis and postoperative inflammation. It is a good antioxidant, and recently it has been found useful in chemoprevention, chemosuppression, and UV protection.MLX is a selective COX-2 inhibitor, with high selectivity and fewer gastrointestinal side effects. Due to MLX is a drug with good absorption in the colonic region, its properties against colon cancer and other diseases in this area are being studied, so it is interesting to investigate new formulations for colonic administration of MLX. This thesis studies the behavior of granules without and with 5% cellulose and with a type of Eudragit® (RS, FS or NM), or with mixtures of the polymers RS + FS and NM + FS...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia Galénica y Tecnología Alimentaria, leída el 27-11-2020