A novel hemocompatible core@shell nanosystem for selective targeting and apoptosis induction in cancer cells.

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Aragoneses Cazorla, Guillermo and Serrano López, Juana and Martínez Alfonzo, Inés and Vallet Regí, María and González Ortiz, Blanca and Luque-García, José L. (2021) A novel hemocompatible core@shell nanosystem for selective targeting and apoptosis induction in cancer cells. Inorganic Chemistry Frontiers, 8 . pp. 2697-2712. ISSN 2052-1553

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Official URL: https://doi.org/10.1039/D1QI00143D




Abstract

One of the main problems with drug-based cancer treatments is the lack of selectivity, which causes them to be distributed non-specifically in the body and cells, generating undesirable side effects. In this work, a novel hybrid nanosystem for cancer cell targeting and therapeutic delivery of Ag nanoparticles has been designed. The proposed nanosystem contains a Ag core coated with a mesoporous silica shell which prevents the aggregation of Ag nanoparticles and allows the anchoring of transferrin as a targeting ligand, thus enabling the nanosystem to be selectively directed to cancer cells that overexpress transferrin receptors. The analytical and functional characterization of the nanosystem has allowed to demonstrate selective internalization and its cytotoxic potential in cancer cells where it induces apoptosis. Additional bioanalytical experiments have enabled the identification of different transcripts and altered proteins in cells treated with the nanosystem, which has made it possible to delve deeper into the biomolecular mechanisms by which the nanosystem exerts its action. Furthermore, a hemocompatibility study indicates neither activation of monocytes nor platelet aggregation after nanosystem exposure, hence supporting the future clinical applicability of the Ag@MSNs-Tf nanosystem.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID K-4773-2015 (Blanca González Ortiz)
ORCID 0000-0002-0493-6071 (Blanca González Ortiz)

Uncontrolled Keywords:mesoporous silica nanoparticles, silver nanoparticles, core@shell nanosystem, nanoparticles hemocompatibility
Subjects:Sciences > Chemistry > Materials
ID Code:66065
Deposited On:10 Jun 2021 15:54
Last Modified:10 Jun 2021 15:54

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