The Lack of Light-Dark and Feeding-Fasting Cycles Alters Temporal Events in the Goldfish (Carassius auratus) Stress Axis

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Saiz, Nuria and Gómez-Boronat, Miguel and Pedro Ormeño, Nuria de and Delgado Saavedra, María Jesús and Isorna Alonso, Esther (2021) The Lack of Light-Dark and Feeding-Fasting Cycles Alters Temporal Events in the Goldfish (Carassius auratus) Stress Axis. Animals, 11 (3). pp. 1-19. ISSN 2076-2615

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Official URL: https://doi.org/10.3390/ani11030669




Abstract

Vertebrates possess circadian clocks, driven by transcriptional–translational loops of clock genes, to orchestrate anticipatory physiological adaptations to cyclic environmental changes. This work aims to investigate how the absence of a light-dark cycle and a feeding schedule impacts the oscillators in the hypothalamus-pituitary-interrenal axis of goldfish. Fish were maintained under 12L:12D feeding at ZT 2; 12L:12D feeding at random times; and constant darkness feeding at ZT 2. After 30 days, fish were sampled to measure daily variations in plasma cortisol and clock gene expression in the hypothalamus-pituitary-interrenal (HPI) axis. Clock gene rhythms in the HPI were synchronic in the presence of a light-dark cycle but were lost in its absence, while in randomly fed fish, only the interrenal clock was disrupted. The highest cortisol levels were found in the randomly fed group, suggesting that uncertainty of food availability could be as stressful as the absence of a light-dark cycle. Cortisol daily rhythms seem to depend on central clocks, as a disruption in the adrenal clock did not impede rhythmic cortisol release, although it could sensitize the tissue to stress.


Item Type:Article
Uncontrolled Keywords:Chronobiology; Circadian system; Animal welfare; Fish biology; Clock genes
Subjects:Medical sciences > Biology > Animal physiology
Medical sciences > Biology > Fishes
ID Code:66066
Deposited On:10 Jun 2021 10:36
Last Modified:23 Nov 2021 12:53

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