Publication: Desarrollo de nuevas formulaciones de ezetimiba y ezetimiba/atorvastatina en el tratamiento de la hipercolesterolemia
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2021-06-11
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Universidad Complutense de Madrid
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Abstract
Los niveles elevados de colesterol y las concentraciones anormales de algunos lípidos y lipoproteínas en sangre, se consideran factores de riesgo de enfermedades cardiovasculares y distintos síndromes metabólicos. El aumento de colesterol y lipoproteínas puede deberse a factores genéticos como la hipercolesterolemia familiar o la hiperlipidemia familiar combinada y factores externos como el tabaco, una disminución de la actividad física y una dieta rica en grasas saturadas. Una de las causas más frecuente de enfermedad cardiovascular es la aterosclerosis o enfermedad aterosclerótica vascular, que implica la formación de placas de ateroma constituidas por la acumulación de colesterol, triglicéridos, y otras sustancias que circulan por el torrente sanguíneo y quedan adheridas a las paredes de los vasos...
High cholesterol levels and abnormal concentrations of certain lipids and lipoproteins in blood are considered risk factors for cardiovascular diseases and a range of metabolic syndromes. Increases in cholesterol and lipoproteins may be caused by genetic factors such as familial hypercholesterolemia or familial combined hyperlipidemia and external factors such as smoking, a decline in physical activity and a diet high in saturated fats.One of the most frequent causes of cardiovascular disease is atherosclerosis or atherosclerotic cardiovascular disease, which involves the formation of atheromatous plaques due to the accumulation of cholesterol, triglycerides and other substances that circulate via the bloodstream and become adhered to the walls of the blood vessels...
High cholesterol levels and abnormal concentrations of certain lipids and lipoproteins in blood are considered risk factors for cardiovascular diseases and a range of metabolic syndromes. Increases in cholesterol and lipoproteins may be caused by genetic factors such as familial hypercholesterolemia or familial combined hyperlipidemia and external factors such as smoking, a decline in physical activity and a diet high in saturated fats.One of the most frequent causes of cardiovascular disease is atherosclerosis or atherosclerotic cardiovascular disease, which involves the formation of atheromatous plaques due to the accumulation of cholesterol, triglycerides and other substances that circulate via the bloodstream and become adhered to the walls of the blood vessels...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 12-11-2020