Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population



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Valero Velló, Mar and Peris Martínez, Cristina and García Medina, José Javier and Sanz González, Silvia María and Ramírez Sebastián, Ana Isabel and Fernández Albarral, José Antonio and Galarreta Mira, David and Zanón Moreno, Vicente and Casaroli Marano, Ricardo P. and Pinazo Durán, Mª Dolores (2021) Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population. Foods, 10 (6). ISSN 2304-8158

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Adherence to a healthy diet offers a valuable intervention to compete against the increas ing cases of ocular diseases worldwide, such as dry eye disorders, myopia progression, cataracts, glaucoma, diabetic retinopathy, or age macular degeneration. Certain amounts of micronutrients must be daily provided for proper functioning of the visual system, such as vitamins, carotenoids, trace metals and omega-3 fatty acids. Among natural foods, the following have to be considered for boosting eye/vision health: fish, meat, eggs, nuts, legumes, citrus fruits, nuts, leafy green vegetables, orange-colored fruits/vegetables, olives-olive oil, and dairy products. Nutritional supplements have received much attention as potential tools for managing chronic-degenerative ocular diseases. A systematic search of PubMed, Web of Science, hand-searched publications and historical archives were performed by the professionals involved in this study, to include peer-reviewed articles in which natural food, nutrient content, and its potential relationship with ocular health. Five ophthalmologists and two researchers collected the characteristics, quality and suitability of the above studies. Finally, 177 publications from 1983 to 2021 were enclosed, mainly related to natural food, Mediterranean diet (MedDiet) and nutraceutic supplementation. For the first time, original studies with broccoli and tigernut (chufa de Valencia) regarding the ocular surface dysfunction, macular degeneration, diabetic retinopathy and glaucoma were enclosed. These can add value to the diet, counteract nutritional defects, and help in the early stages, as well as in the course of ophthalmic pathologies. The main purpose of this review, enclosed in the Special Issue “Health Benefits and Nutritional Quality of Fruits, Nuts and Vegetables,” is to identify directions for further research on the role of diet and nutrition in the eyes and vision, and the potential antioxidant, anti-inflammatory and neuroprotec tive effects of natural food (broccoli, saffron, tigernuts and walnuts), the Mediterranean Diet, and nutraceutic supplements that may supply a promising and highly affordable scenario for patients at risk of vision loss. This review work was designed and carried out by a multidisciplinary group involved in ophthalmology and ophthalmic research and especially in nutritional ophthalmology.

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Received: 18 April 2021 / Revised: 24 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021.
This article belongs to the Special Issue Health Benefits and Nutritional Quality of Fruits, Nuts, and Vegetables.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

Uncontrolled Keywords:Eye diseases; Natural food; Antioxidant/anti-inflammatory/neuroprotective properties; Broccoli; Saffron; Tigernuts-chufa de Valencia; Walnuts; Mediterranean diet; Nutritional supplements
Subjects:Medical sciences > Medicine > Physiology
Medical sciences > Medicine > Ophtalmology
ID Code:66211
Deposited On:22 Jun 2021 11:46
Last Modified:22 Jun 2021 11:46

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