Glomerular Hematuria: Cause or Consequence of Renal Inflammation?

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Moreno, Juan Antonio and Sevillano, Ángel and Gutiérrez, Eduardo and Guerrero-Hue, Melania and Vázquez-Carballo, Cristina and Yuste, Claudia and Herencia, Carmen and García-Caballero, Cristina and Praga Terente, Manuel and Egido, Jesús (2019) Glomerular Hematuria: Cause or Consequence of Renal Inflammation? International Journal of Molecular Sciences, 20 (9). p. 2205. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20092205




Abstract

Glomerular hematuria is a cardinal symptom of renal disease. Glomerular hematuria may be classified as microhematuria or macrohematuria according to the number of red blood cells in urine. Recent evidence suggests a pathological role of persistent glomerular microhematuria in the progression of renal disease. Moreover, gross hematuria, or macrohematuria, promotes acute kidney injury (AKI), with subsequent impairment of renal function in a high proportion of patients. In this pathological context, hemoglobin, heme, or iron released from red blood cells in the urinary space may cause direct tubular cell injury, oxidative stress, pro-inflammatory cytokine production, and further monocyte/macrophage recruitment. The aim of this manuscript is to review the role of glomerular hematuria in kidney injury, the role of inflammation as cause and consequence of glomerular hematuria, and to discuss novel therapies to combat hematuria.


Item Type:Article
Uncontrolled Keywords:hematuria; inflammation; oxidative stress; tubular injury; AKI; chronic kidney disease
Subjects:Medical sciences > Medicine > Nephrology and Urology
ID Code:66251
Deposited On:21 Jun 2021 08:59
Last Modified:21 Jun 2021 09:02

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