dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies

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Palomares Gracia, Óscar and Sánchez Ramón, Silvia María and Dávila, Ignacio and Prieto, Luis and Pérez de Llano, Luis and Lleonart, Marta and Domingo, Christian and Nieto, Antonio (2017) dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies. International Journal of Molecular Sciences, 18 (6). p. 1328. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms18061328




Abstract

Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. The most common associated feature in the airways of patients with asthma is airway inflammation. In recent decades, efforts have been made to characterise the heterogeneous clinical nature of asthma. The interest in improving the definitions of asthma phenotypes and endotypes is growing, although these classifications do not always correlate with prognosis nor are always appropriate therapeutic approaches. Attempts have been made to identify the most relevant molecular and cellular biomarkers underlying the immunopathophysiological mechanisms of the disease. For almost 50 years, immunoglobulin E (IgE) has been identified as a central factor in allergic asthma, due to its allergen-specific nature. Many of the mechanisms of the inflammatory cascade underlying allergic asthma have already been elucidated, and IgE has been shown to play a fundamental role in the triggering, development, and chronicity of the inflammatory responses within the disease. Blocking IgE with monoclonal antibodies such as omalizumab have demonstrated their efficacy, effectiveness, and safety in treating allergic asthma. A better understanding of the multiple contributions of IgE to the inflammatory continuum of asthma could contribute to the development of novel therapeutic strategies for the disease.


Item Type:Article
Uncontrolled Keywords:allergy; asthma; immunoglobulin E (IgE); biomarkers; immunological mechanisms; immunomodulation; biological treatment; anti-IgE; omalizumab
Subjects:Sciences > Chemistry > Molecular biology
Sciences > Chemistry > Biochemistry
Medical sciences > Medicine > Medical microbiology
ID Code:66287
Deposited On:22 Jun 2021 15:31
Last Modified:23 Jun 2021 06:50

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