Flavanol Bioavailability in Two Cocoa Products with Different Phenolic Content. A Comparative Study in Humans

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Gómez Juaristi, Miren and Sarria, Beatriz and Martínez-López, Sara and Bravo Clemente, Laura and Mateos, Raquel (2019) Flavanol Bioavailability in Two Cocoa Products with Different Phenolic Content. A Comparative Study in Humans. Nutrients, 11 (7). p. 1441. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu11071441




Abstract

Cocoa has beneficial health effects partly due to its high flavanol content. This study was aimed at assessing the absorption and metabolism of polyphenols in two soluble cocoa products: a conventional (CC) and a flavanol-rich product (CC-PP). A crossover, randomized, blind study was performed in 13 healthy men and women. On two different days, after an overnight fast, volunteers consumed one serving of CC (15 g) or CC-PP (25 g) in 200 mL of semi-skimmed milk containing 19.80 mg and 68.25 mg of flavanols, respectively. Blood and urine samples were taken, before and after CC and CC-PP consumption, and analyzed by high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QToF-MS). Up to 10 and 30 metabolites were identified in plasma and urine, respectively. Phase II derivatives of epicatechin were identified with kinetics compatible with small intestine absorption, although the most abundant groups of metabolites were phase II derivatives of phenyl-γ-valerolactone and phenylvaleric acid, formed at colonic level. 5-(4′-Hydroxyphenyl)-γ-valerolactone-sulfate could be a sensitive biomarker of cocoa flavanol intake. CC and CC-PP flavanols showed a dose-dependent absorption with a recovery of 35%. In conclusion, cocoa flavanols are moderately bioavailable and extensively metabolized, mainly by the colonic microbiota.


Item Type:Article
Uncontrolled Keywords:flavanols; soluble cocoa products; bioavailability; human; plasma nutrikinetics; liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (LC-ESI-QToF-MS); colonic bacteria
Subjects:Sciences > Chemistry
Sciences > Chemistry > Nutrition
Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Dietetics and Nutrition
ID Code:66342
Deposited On:23 Jun 2021 11:12
Last Modified:23 Jun 2021 11:21

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