Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

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Papandreou, Christopher and Babio, Nancy and Díaz-López, Andrés and Martínez-González, Miguel and Becerra-Tomas, Nerea and Corella, Dolores and Schröder, Helmut and Romaguera, Dora and Vioque, Jesús and Alonso-Gómez, Ángel and Wärnberg, Julia and Martínez, Alfredo and Serra-Majem, Lluís and Estruch, Ramon and Muñoz-Garach, Araceli and Lapetra, José and Pintó, Xavier and Tur, Josep and Garcia-Rios, Antonio and Bueno-Cavanillas, Aurora and Delgado-Rodríguez, Miguel and Matía Martín, Pilar and Daimiel, Lidia and Martín-Sánchez, Vicente and Vidal, Josep and Vázquez, Clotilde and Ros, Emilio and Ruiz-Canela, Miguel and Bulló, Mónica and Sorli, Jose and Quifer, Mireia and Colom, Antoni and Oncina-Canovas, Alejandro and Tojal-Sierra, Lucas and Barón-López, Javier and Pérez-Farinós, Napoleón and Abete, Itziar and Sanchez-Villegas, Almudena and Casas, Rosa and Fernández-Garcia, José and Santos-Lozano, José and Corbella, Emili and del M. Bibiloni, Maria and Diez-Espino, Javier and Asensio, Eva and Torras, Laura and Morey, Marga and Compañ-Gabucio, Laura and Salaverria-Lete, Itziar and Cenoz-Osinaga, Juan and Castañer, Olga and Salas-Salvadó, Jordi (2019) Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk. Nutrients, 11 (4). p. 761. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu11040761




Abstract

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.


Item Type:Article
Uncontrolled Keywords:sleep duration; actigraphy; serum uric acid; serum uric acid to creatinine ratio
Subjects:Medical sciences > Medicine > Cardiology
Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Nephrology and Urology
ID Code:66344
Deposited On:23 Jun 2021 11:27
Last Modified:23 Jun 2021 11:28

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