Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives

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Alcaide, Benito and Almendros, Pedro and Alonso Gómez, José Miguel (2011) Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives. Molecules, 16 (9). pp. 7815-7843. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules16097815




Abstract

The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.


Item Type:Article
Uncontrolled Keywords:gold catalysis; alkynols; total synthesis; natural products
Subjects:Sciences > Chemistry > Chemistry, Organic
ID Code:66552
Deposited On:29 Jun 2021 15:27
Last Modified:07 Jul 2021 07:37

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