Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections.

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Castillo Romero, Rafael and Vallet Regí, María (2021) Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections. International Journal of Nanomedicine, 16 . pp. 4409-4430. ISSN 1178-2013

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Official URL: https://www.dovepress.com/international-journal-of-nanomedicine-journal




Abstract

It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination
with additional features like membrane sensitizing and heavy metal-driven metabolicdisrupting therapies as two of the most interesting combination therapies


Item Type:Article
Additional Information:

RESEARCH ID L-2854-2014  (Rafael Castillo Romero)
ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:mesoporous silica, bacteria, infection, combination therapy, drug delivery
Subjects:Sciences > Chemistry > Materials
ID Code:66590
Deposited On:07 Jul 2021 07:47
Last Modified:07 Jul 2021 08:54

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