Publication: Modulación del perfil transcripcional y funcional de macrófagos humanos por el recepetor de serotonina 5-HT2b y el factor de transcripción AhR
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2021-07-06
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Universidad Complutense de Madrid
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Abstract
Los macrófagos son células del sistema inmune innato con la capacidad de adquirir una amplia heterogeneidad fenotípica y funcional (polarización), lo que les permite adaptarse a los requerimientos del microambiente en el que se encuentran. El abanico de estados de polarización de macrófagos viene dictado por señales extracelulares, por su ontogenia y por los estímulos activadores procedentes del medio. Dicha versatilidad les permite estar implicados en el mantenimiento de la homeostasis, al participar en la eliminación de patógenos, la reparación tisular, la cicatrización de heridas y la iniciación y resolución de respuestas inflamatorias. Por todo ello, resulta capital el conocimiento de las bases moleculares de la polarización de macrófagos como paso intermedio para el desarrollo de estrategias terapéuticas frente a patologías derivadas de, o asociadas con, una polarización de macrófagos alterada o desregulada (artritis reumatoide, aterosclerosis, cáncer, esclerosis múltiple, etc.…)...
Macrophages are cells of the innate immune system able to acquire a broad phenotypic and functional range (polarization). This feature allows them to adapt to the requirements of the microenvironment. The range of macrophage polarization states is dictated by extracellular signals, their ontogeny and the activating stimuli from the environment. This versatility allows them to be involved in the maintenance of homeostasis, participating in the elimination of pathogens, tissue repair, wound healing, and in the initiation and resolution of inflammatory responses. Therefore, knowledge of the molecular basis of macrophage polarization is an intermediate step for the development of therapeutic strategies for pathologies derived from, or associated with, an altered or deregulated macrophage polarization, such as rheumatoid arthritis, atherosclerosis, cancer, multiple sclerosis, etc... As critical regulators of inflammatory processes, macrophages are the target of numerous agents and molecules with pro- or anti-inflammatory activities. One of them is peripheral serotonin (5-HT), a biogenic amine that has a plethora of functions, including its well-known role as neurotransmitter...
Macrophages are cells of the innate immune system able to acquire a broad phenotypic and functional range (polarization). This feature allows them to adapt to the requirements of the microenvironment. The range of macrophage polarization states is dictated by extracellular signals, their ontogeny and the activating stimuli from the environment. This versatility allows them to be involved in the maintenance of homeostasis, participating in the elimination of pathogens, tissue repair, wound healing, and in the initiation and resolution of inflammatory responses. Therefore, knowledge of the molecular basis of macrophage polarization is an intermediate step for the development of therapeutic strategies for pathologies derived from, or associated with, an altered or deregulated macrophage polarization, such as rheumatoid arthritis, atherosclerosis, cancer, multiple sclerosis, etc... As critical regulators of inflammatory processes, macrophages are the target of numerous agents and molecules with pro- or anti-inflammatory activities. One of them is peripheral serotonin (5-HT), a biogenic amine that has a plethora of functions, including its well-known role as neurotransmitter...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Bioquímica y Biología Molecular, leída el 14/09/2020