A BODIPY-Based Fluorescent Sensor for Amino Acids Bearing Thiol



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Avellanal-Zaballa, Edurne and Ramos Torres, Ágata and Prieto Castañeda, Alejandro and García Garrido, Fernando and Bañuelos, Jorge and Rodríguez Agarrabeitia, Antonia and Ortíz García, María Josefa (2019) A BODIPY-Based Fluorescent Sensor for Amino Acids Bearing Thiol. Proceedings, 41 (1). p. 18. ISSN 2504-3900

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Official URL: https://doi.org/10.3390/ecsoc-23-06486


Herein, we describe the synthetic route to access a red-emitting BODIPY from its α-diformylated precursor. The photophysical signatures of this dye are sensitive to the presence of thiol-containing amino acids (like cysteine, homocysteine, and glutathione) in the surrounding environment. This sensor provides up to three detection channels to monitor and quantify these biomolecules, even at low concentrations (down to micromolar). Moreover, owing to the pronounced splitting of the spectral band profile induced by these amino acids, the detection can be visualized following just the evolution of the fluorescence color by the naked eye.

Item Type:Article
Uncontrolled Keywords:dye chemistry; fluorescent sensors; BODIPY; amino acids; Wittig reaction
Subjects:Sciences > Chemistry > Chemistry, Organic
ID Code:66784
Deposited On:12 Jul 2021 14:02
Last Modified:13 Jul 2021 06:44

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