In-silico modeling of early-stage biofilm formation



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Nie, Pin and Alarcón, Francisco and López-Montero, Iván and Orgaz, Belén and Valeriani, Chantal and Pica Ciamarra, Massimo (2021) In-silico modeling of early-stage biofilm formation. Soft materials . ISSN 1539-445X

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Bacteria can form biofilms in different environmental conditions, e.g. pH, temperature, nutrients, etc. Biofilm growth, therefore, is an extremely robust process. Because of this, while biofilm growth is a complex process affected by several variables, insights into biofilm formation could be obtained by studying simple schematic models. In this manuscript, we describe a hybrid molecular dynamics and Monte Carlo model for the simulation of the early stage formation of a biofilm, to explicitly demonstrate that it is possible to account for most of the processes expected to be relevant. The simulations account for the growth and reproduction of the bacteria, for their interaction and motility, for the synthesis of extracellular polymeric substances and exopolisaccharide trails. We describe the effect of these processes on the early stage formation of biofilms, in two dimensions, and also discuss preliminary three-dimensional results.

Item Type:Article
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This work was supported by the Ministry of Education Singapore [2019-T1-001-03].

Uncontrolled Keywords:Biofilm; Microcolonies; Bacterial growth; Numerical simulations
Subjects:Sciences > Physics > Nuclear physics
ID Code:66887
Deposited On:26 Jul 2021 10:06
Last Modified:18 Aug 2021 11:03

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