Publication: Caracterización Molecular de Cáncer Colorrectal Metacrónico
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2021-07-19
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Universidad Complutense de Madrid
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Abstract
El cáncer colorrectal (CCR) es uno de los tumores malignos más comunes, siendo el segundo cáncer más mortal a nivel mundial. El CCR es una enfermedad molecularmente heterogénea desarrollada a través de diferentes vías de carcinogénesis, donde se encuentran implicados cambios genéticos y epigenéticos. Los pacientes diagnosticados de CCR poseen un riesgo aumentado de desarrollar otras lesiones a lo largo del colon tras la cirugía - CCR metacrónico (CCRM) -. A pesar de que los estudios genómicos realizados han mejorado nuestra capacidad para identificar los cambios moleculares asociados al CCR, la base molecular y los factores de riesgo asociados al CCRM continúan siendo poco conocidos. Las evidencias sugieren que los síndromes de CCR hereditario son uno de los factores de riesgo de CCRM, aunque en la actualidad aún se desconoce cuáles de los pacientes son propensos a esta afección...
Colorectal cancer (CRC) is one of the most common malignant tumors, being the second cancer with the highest mortality worldwide. CRC is a heterogeneous disease that develops through different carcinogenic pathways, where both genetic and epigenetic changes are involved.Patients diagnosed with CRC have an increased risk of developing other lesions along the colon after surgery, detected during follow-up - metachronous CRC (MCRC) -. Although genomic studies carried out have improved our ability to identify the molecular changes associated with CRC, molecular basis and risk factors associated with MCRC remain poorly understood. Evidence suggests that hereditary CRC syndromes are one of the risk factors for developing MCRC, however it is still unknown which patients are prone to this condition...
Colorectal cancer (CRC) is one of the most common malignant tumors, being the second cancer with the highest mortality worldwide. CRC is a heterogeneous disease that develops through different carcinogenic pathways, where both genetic and epigenetic changes are involved.Patients diagnosed with CRC have an increased risk of developing other lesions along the colon after surgery, detected during follow-up - metachronous CRC (MCRC) -. Although genomic studies carried out have improved our ability to identify the molecular changes associated with CRC, molecular basis and risk factors associated with MCRC remain poorly understood. Evidence suggests that hereditary CRC syndromes are one of the risk factors for developing MCRC, however it is still unknown which patients are prone to this condition...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Bioquímica y Biología Molecular, leída el 01/12/2020