Publication: Criotransferencia embrionaria en día 4 de cultivo frente a día 3.Resultados reproductivos, obstétricos y perinatales obtenidos
Loading...
Files
Official URL
Full text at PDC
Publication Date
2021-07-20
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
Decidir el mejor momento para realizar la transferencia embrionaria (TE) ha sido y sigue siendo un tema controvertido (1). Las transferencias embrionarias realizadas en día 3 y 5 de cultivo han sido estudiadas ampliamente, sin embargo, no ocurre igual con el día 4 (2). La TE en día 4 está escasamente referenciada en la literatura y la principal causa de ello, es que los parámetros morfológicos establecidos para la selección embrionaria de las mórulas presentan mayor variabilidad interobservador y son más difíciles de valorar desde el punto de vista de la embriología clínica (3)(4). Los embriones en día 4 cuentan con un día adicional de cultivo in vitro con respecto al día 3, un día más de observación y evaluación que permite al embriólogo realizar una mejor selección embrionaria. Los embriones que alcanzan la fase de mórula han superado los hitos de activación del genoma y compactación, ambos considerados puntos críticos en la evolución embrionaria (4)...
Still the best moment to proceed with the embryo transfer remains a controversial topic. Day 3 and day 5 embryo transfers (ET) have been widely studied, in contrast to day 4 transfers. Day 4 ET has been barely referenced in literature, and this is mainly because the morphological parameters established for the selection of morula embryo are hard to evaluate due to interobserver variability and the subjectivity of the embryologist. An additional day of observation and evaluation allows to better select the embryos in comparison to day 3. Those embryos becoming morula have overcome the milestones of genome activation and compaction, which are deemed to be critical points in the embryo evolution.Other day 4 ET- related advantages are as follows: to allow for an increase of flexibility to choose transfer day, to transfer in a more physiological moment with less uterine contractility, and a shorter in vitro period of time could reduce the risk of epigenetic/genetic alterations, fetal malformations, monozygotic twins and preterm newborn, which are all disadvantages related to blastocyst ET...
Still the best moment to proceed with the embryo transfer remains a controversial topic. Day 3 and day 5 embryo transfers (ET) have been widely studied, in contrast to day 4 transfers. Day 4 ET has been barely referenced in literature, and this is mainly because the morphological parameters established for the selection of morula embryo are hard to evaluate due to interobserver variability and the subjectivity of the embryologist. An additional day of observation and evaluation allows to better select the embryos in comparison to day 3. Those embryos becoming morula have overcome the milestones of genome activation and compaction, which are deemed to be critical points in the embryo evolution.Other day 4 ET- related advantages are as follows: to allow for an increase of flexibility to choose transfer day, to transfer in a more physiological moment with less uterine contractility, and a shorter in vitro period of time could reduce the risk of epigenetic/genetic alterations, fetal malformations, monozygotic twins and preterm newborn, which are all disadvantages related to blastocyst ET...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 03/11/2020