Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

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Tacias-Pascacio, Veymar G. and Ortiz, Claudia and Rueda, Nazzoly and Berenguer-Murcia, Ángel and Acosta Contreras, Niuris and Aranaz Corral, Inmaculada and Civera Tejuca, María Concepción and Fernandez-Lafuente, Roberto and Alcántara León, Andrés Rafael (2019) Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System. Catalysts, 9 (7). p. 622. ISSN 2073-4344

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Official URL: https://doi.org/10.3390/catal9070622




Abstract

Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that is very useful in many areas, including as a macromolecular carrier for drug delivery and other biomedical applications. In particular, it has been widely used for chemical engineering of enzymes, with the aim of designing better biocatalysts that possess improved catalytic properties, making them more stable and/or active for different catalytic reactions. This polymer possesses a very flexible hydrophilic structure, which becomes inert after chemical reduction; therefore, dexOx comes to be highly versatile in a biocatalyst design. This paper presents an overview of the multiple applications of dexOx in applied biocatalysis, e.g., to modulate the adsorption of biomolecules on carrier surfaces in affinity chromatography and biosensors design, to serve as a spacer arm between a ligand and the support in biomacromolecule immobilization procedures or to generate artificial microenvironments around the enzyme molecules or to stabilize multimeric enzymes by intersubunit crosslinking, among many other applications.


Item Type:Article
Uncontrolled Keywords:dextran; dextran-aldehyde; enzyme immobilization; enzyme modification
Subjects:Medical sciences > Pharmacy > Pharmaceutical chemistry
ID Code:67098
Deposited On:28 Jul 2021 13:57
Last Modified:19 Aug 2021 07:16

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