BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration



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Herrera González, Blanca and Addante, Annalisa and Sánchez Muñoz, Aránzazu (2017) BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration. International Journal of Molecular Sciences, 19 (1). p. 39. ISSN 1422-0067

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Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions. In an attempt to provide the basis for guiding research efforts in this field both the more solid and more controversial areas of research were highlighted.

Item Type:Article
Uncontrolled Keywords:BMP; liver; fibrosis; regeneration; TGF-β; chronic liver disease
Subjects:Medical sciences > Pharmacy > Molecular biology
Medical sciences > Pharmacy > Biochemistry
ID Code:67119
Deposited On:21 Jul 2021 15:06
Last Modified:18 Aug 2021 08:29

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