Glucagon, GLP-1 and Thermogenesis



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González-García, Ismael and Milbank, Edward and Diéguez, Carlos and López, Miguel and Contreras Jiménez, Cristina (2019) Glucagon, GLP-1 and Thermogenesis. International Journal of Molecular Sciences, 20 (14). p. 3445. ISSN 1422-0067

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Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.

Item Type:Article
Uncontrolled Keywords:glucagon; GLP1; thermogenesis; brown adipose tissue; browning; hypothalamic control of energy balance
Subjects:Medical sciences > Pharmacy > Pharmacology
ID Code:67122
Deposited On:21 Jul 2021 15:02
Last Modified:18 Aug 2021 08:24

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