Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy

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Fernández-Nogueira, Patricia and Mancino, Mario and Fuster, Gemma and Bragado Domingo, Paloma and Prats de Puig, Miquel and Gascón, Pere and Casado, Francisco Javier and Carbó, Neus (2020) Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy. Journal of Clinical Medicine, 9 (3). p. 776. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm9030776




Abstract

Current evidences state clear that both normal development of breast tissue as well as its malignant progression need many-sided local and systemic communications between epithelial cells and stromal components. During development, the stroma, through remarkably regulated contextual signals, affects the fate of the different mammary cells regarding their specification and differentiation. Likewise, the stroma can generate tumour environments that facilitate the neoplastic growth of the breast carcinoma. Mammographic density has been described as a risk factor in the development of breast cancer and is ascribed to modifications in the composition of breast tissue, including both stromal and glandular compartments. Thus, stroma composition can dramatically affect the progression of breast cancer but also its early detection since it is mainly responsible for the differences in mammographic density among individuals. This review highlights both the pathological and biological evidences for a pivotal role of the breast stroma in mammographic density, with particular emphasis on dense and malignant stromas, their clinical meaning and potential therapeutic implications for breast cancer patients.


Item Type:Article
Uncontrolled Keywords:tumour stroma; mammographic density; therapy resistance; ductal carcinoma in situ (DCIS); invasive ductal carcinoma (IDC); breast cancer detection
Subjects:Medical sciences > Pharmacy > Diagnosis, laboratory
Medical sciences > Pharmacy > Molecular biology
Medical sciences > Pharmacy > Biochemistry
ID Code:67127
Deposited On:20 Jul 2021 14:35
Last Modified:17 Aug 2021 08:53

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