Publication: La vía kinurenina como una posible diana farmacológica en el abuso de alcohol y su regulación por la microbiota intestinal
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2021-07-21
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Universidad Complutense de Madrid
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Abstract
El etanol (EtOH) es el principal componente de las bebidas alcohólicas. Se consume debido a sus efectos placenteros, relajantes y reforzantes pero no se puede obviar que 1 de cada 20 muertes que se producen en el mundo son directamente atribuibles al consumo de EtOH (1). EtOH actúa en el cerebro a través de múltiples mecanismos que implican diversos sistemas de neurotransmisión, aunque el sistema dopaminérgico es el que juega un papel fundamental en relación a los efectos reforzantes que permiten que los individuos continúen consumiendo EtOH de forma abusiva (2). El metabolismo de EtOH es principalmente oxidativo y puede producirse a lo largo de todo el tracto gastrointestinal (3). Esto abre la puerta a que el consumo de EtOH pueda guardar relación con la microbiota intestinal y pueda ejercer parte de los efectos observados en el cerebro a través del eje microbiota-intestino-cerebro, eje que ya se ha caracterizado en otras enfermedades mentales (4–9)...
Ethanol (EtOH) is the main component of alcoholic beverages. It is consumed because of its pleasurable, relaxing and reinforcing effects. However, the fact that 1 in 20 deaths in the world is directly attributable to EtOH consumption (1) cannot be overlooked EtOH produces its effects in the brain through multiple mechanisms involving diverse neurotransmission systems, although the dopaminergic system is the key player in the reinforcing effects which drive individuals to engage in abusive EtOH consumption (2). EtOH metabolism is mainly oxidative and can take place throughout the digestive system (3). This fact suggests that EtOH could be related to gut microbiota and that part of its effects may be exerted through the gut-microbiota-brain axis, which has been characterized in other mental illnesses (4–9)...
Ethanol (EtOH) is the main component of alcoholic beverages. It is consumed because of its pleasurable, relaxing and reinforcing effects. However, the fact that 1 in 20 deaths in the world is directly attributable to EtOH consumption (1) cannot be overlooked EtOH produces its effects in the brain through multiple mechanisms involving diverse neurotransmission systems, although the dopaminergic system is the key player in the reinforcing effects which drive individuals to engage in abusive EtOH consumption (2). EtOH metabolism is mainly oxidative and can take place throughout the digestive system (3). This fact suggests that EtOH could be related to gut microbiota and that part of its effects may be exerted through the gut-microbiota-brain axis, which has been characterized in other mental illnesses (4–9)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 30/11/2020