Publication: MicroARNs en asma: biomarcadores de enfermedad asmática, fenotipos de gravedad y posibles herramientas terapéuticas
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2021-08-18
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Universidad Complutense de Madrid
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Abstract
El asma es una enfermedad respiratoria crónica que se caracteriza por tos, sibilancias y dificultad respiratoria causada principalmente por la exacerbación de la respuesta inflamatoria fisiológica. Particularmente, las células involucradas en esta enfermedad forman parte, tanto de la inmunidad adaptativa (los linfocitos cooperadores, los T y los B), como de la inmunidad innata, de la cual forman parte las células dendríticas, los macrófagos, o los eosinófilos, de particular importancia en el asma. Los eosinófilos son granulocitos capaces de inducir respuestas proinflamatorias mediante la liberación del contenido de sus gránulos y, también, de sus exosomas. Concretamente, lo sexosomas son vesículas extracelulares secretadas por las células, capaces de ejercer un efectos obre el comportamiento de las células receptoras de los mismos..
Asthma is a chronic respiratory disease of the airways characterized by coughing, wheezing and breathing difficulty, caused by an exacerbation of physiological inflammatory responses. In particular, the main cells involved in this disease belong to, both adaptive immunity, such as helper lymphocytes, T and B cells; and innate immunity, including dendritic cells, macrophages, or eosinophils, which are particularly important in asthma. Eosinophils are granulocytes capable of inducing pro-inflammatory responses through the release of their granules and exosomes. Particularly, exosomes are extracellular vesicles secreted by cells that are capable of affecting the behaviour of cells who receive them. This intercellular communication is mediated by proteins and nucleic acids, like microRNAs (miRNAs), which are encapsulated inside exosomes...
Asthma is a chronic respiratory disease of the airways characterized by coughing, wheezing and breathing difficulty, caused by an exacerbation of physiological inflammatory responses. In particular, the main cells involved in this disease belong to, both adaptive immunity, such as helper lymphocytes, T and B cells; and innate immunity, including dendritic cells, macrophages, or eosinophils, which are particularly important in asthma. Eosinophils are granulocytes capable of inducing pro-inflammatory responses through the release of their granules and exosomes. Particularly, exosomes are extracellular vesicles secreted by cells that are capable of affecting the behaviour of cells who receive them. This intercellular communication is mediated by proteins and nucleic acids, like microRNAs (miRNAs), which are encapsulated inside exosomes...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 21-05-2021