The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast



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Sanz Santamaría, Ana Belén and García Sánchez, Raúl and Rodríguez Peña, José Manuel and Arroyo, Javier (2017) The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast. Journal of Fungi, 4 (1). p. 1. ISSN 2309-608X

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Fungi are surrounded by an essential structure, the cell wall, which not only confers cell shape but also protects cells from environmental stress. As a consequence, yeast cells growing under cell wall damage conditions elicit rescue mechanisms to provide maintenance of cellular integrity and fungal survival. Through transcriptional reprogramming, yeast modulate the expression of genes important for cell wall biogenesis and remodeling, metabolism and energy generation, morphogenesis, signal transduction and stress. The yeast cell wall integrity (CWI) pathway, which is very well conserved in other fungi, is the key pathway for the regulation of this adaptive response. In this review, we summarize the current knowledge of the yeast transcriptional program elicited to counterbalance cell wall stress situations, the role of the CWI pathway in the regulation of this program and the importance of the transcriptional input received by other pathways. Modulation of this adaptive response through the CWI pathway by positive and negative transcriptional feedbacks is also discussed. Since all these regulatory mechanisms are well conserved in pathogenic fungi, improving our knowledge about them will have an impact in the developing of new antifungal therapies.

Item Type:Article
Uncontrolled Keywords:cell wall integrity; mitogen-activated protein kinase (MAPK); signal transduction; transcription; gene expression; antifungal
Subjects:Medical sciences > Pharmacy > Cytology
Medical sciences > Pharmacy > Microbiology
ID Code:67487
Deposited On:24 Aug 2021 09:55
Last Modified:24 Aug 2021 09:55

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