Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine

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Astiz, Susana and González Bulnes, Antonio and Astiz, Isabel and Barbero, Alicia and Pesantez-Pacheco, Jose Luis and Garcia-Contreras, Consolacion and Vázquez Gómez, Marta and Heras Molina, Ana (2020) Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine. Pharmaceuticals, 13 (7). p. 142. ISSN 1424-8247

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Official URL: https://doi.org/10.3390/ph13070142




Abstract

The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The translation of these results suggests that childhood obesity increases production of reactive oxygen species (ROS), and therefore systemic oxidative stress. Treatment with metformin would improve such oxidative status.


Item Type:Article
Uncontrolled Keywords:metformin; obesity; oxidative-stress; pediatrics
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Pediatrics
ID Code:67508
Deposited On:25 Aug 2021 11:07
Last Modified:06 Sep 2021 09:21

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