Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease

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López Cuenca, Inés and Hoz Montañana, María Rosa de and Alcántara Rey, Celia and Salobrar García Martín, Elena and Elvira Hurtado, Lorena and Fernández Albarral, José Antonio and Barabash, Ana and Ramírez Toraño, Federico and Frutos Lucas, Jaisalmer de and Salazar Corral, Juan José and Ramírez Sebastián, Ana Isabel and Ramirez Sebastian, Jose Manuel (2021) Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease. Biomedicines, 9 (638). 14 p.. ISSN 2227-9059

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Official URL: https://doi.org/10.3390/biomedicines9060638




Abstract

A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.


Item Type:Article
Additional Information:

Received: 6 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021.

Uncontrolled Keywords:Alzheimer’s; Family history; ApoE ε4; AMD; Choroid; Foveal avascular zone; Hard drusen; Retina; OCT; OCTA
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
ID Code:67509
Deposited On:23 Nov 2021 10:06
Last Modified:23 Nov 2021 12:16

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