Both HCV Infection and Elevated Liver Stiffness Significantly Impacts on Several Parameters of T-Cells Homeostasis in HIV-Infected Patients

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Restrepo, Clara and Álvarez, Beatriz and Valencia Delfa, José Luis and García, Marcial and Navarrete Muñoz, María A. and Ligos, José M. and Cabello, Alfonso and Prieto, Laura and Nistal, Sara and Montoya, María and Górgolas, Miguel and Rallón, Norma and Benito, José M. (2020) Both HCV Infection and Elevated Liver Stiffness Significantly Impacts on Several Parameters of T-Cells Homeostasis in HIV-Infected Patients. Journal of Clinical Medicine, 9 (9). p. 2978. ISSN 2077-0383

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Official URL: https://doi.org/10.3390/jcm9092978




Abstract

1) Background: The role of hepatitis C virus (HCV) co-infection on the T-cell homeostasis disturbances in human immunodeficiency virus (HIV)-infected patients as well as its reversion after HCV eradication with direct acting antivirals (DAAs) therapy has not been yet clarified. We extensively analyzed the effect of HCV co-infection on immune parameters of HIV pathogenesis and its evolution after HCV eradication with DAAs.
(2) Methods: Seventy individuals were included in the study—25 HIV-monoinfected patients, 25 HIV/HCV-coinfected patients and 20 HIV and HCV seronegative subjects. All patients were on antiretroviral therapy and undetectable HIV-viremia. Immune parameters, such as maturation, activation, apoptosis, senescence and exhaustion of T-cells were assessed by flow cytometry. Cross-sectional and longitudinal (comparing pre- and post-DAAs data in HIV/HCV coinfected patients) analyses were performed. Univariate and multivariate (general linear model and canonical discriminant analysis -CDA-) analyses were used to assess differences between groups.
(3) Results—The CDA was able to clearly separate HIV/HCV coinfected from HIV-monoinfected patients, showing a more disturbed T-cells homeostasis in HIV/HCV patients, especially activation and exhaustion of T-cells. Interestingly, those perturbations were more marked in HIV/HCV patients with increased liver stiffness. Eradication of HCV with DAAs restored some but not all the T-cells homeostasis disturbances, with activation and exhaustion of effector CD8 T-cells remaining significantly increased three months after HCV eradication.
(4) Conclusions—HCV co-infection significantly impacts on several immune markers of HIV pathogenesis, especially in patients with increased liver stiffness. Eradication of HCV with DAAs ameliorates but does not completely normalize these alterations. It is of utmost relevance to explore other mechanisms underlying the immune damage observed in HIV/HCV coinfected patients with control of both HIV and HCV replication.


Item Type:Article
Uncontrolled Keywords:HIV/HCV coinfection; T-cell homeostasis disturbances; liver stiffness; immune restoration; DAAs-based therapy
Subjects:Medical sciences > Medicine > Communicable diseases
Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Medicine > Immunology
ID Code:67521
Deposited On:26 Aug 2021 11:14
Last Modified:26 Aug 2021 11:14

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