Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates

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Piotrowicz, Inajara Beatriz Brose and Garcés Rimón, Marta and Moreno-Fernández, Silvia and Aleixandre de Artiñano, Amaya and Salas-Mellado, Myriam and Miguel-Castro, Marta (2020) Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates. Foods, 9 (6). p. 812. ISSN 2304-8158

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Official URL: https://doi.org/10.3390/foods9060812




Abstract

This research aimed to investigate the biological properties of different hydrolysates derived from industrial and laboratory defatted rice bran proteins. Industrial and laboratory defatted rice bran protein concentrates were hydrolyzed with alcalase or flavorzyme. The degree of hydrolysis (DH), oxygen radical absorbance capacity (ORAC), reducing power, total phenolic compounds (TPC), and angiotensin-converting enzyme (ACE) inhibitory activity, were determined in the hydrolysates and the molecular fractions lower than 3 kDa. Systolic blood pressure (SBP) was measured using the tail-cuff method before and after oral administration of 80 mg/kg of different rice bran protein hydrolysate (RBPH) fractions lower than 3 kDa in male spontaneously hypertensive rats (SHR) and normotensive Wistar–Kyoto (WKY) rats. The highest values of in vitro antioxidant activity and TPC were observed in RBPH with alcalase defatted by industry (RBPH2A), and, in all cases, these bioactivities were higher in the molecular fractions lower than 3 kDa. Once again, fractions lower than 3 kDa obtained with alcalase showed a potent ACE inhibitory activity (RBPH1A<3). The administration of RBPH1A<3 caused a significant decrease in the SBP in SHR, where the maximum decrease was reached at 8 h after administration. SBP in WKY rats was not modified after the administration of RBPH1A<3. These results suggest that the rice bran protein hydrolysates obtained from industry after treatment with alcalase could be an interesting source of bioactive peptides, with potential action on hypertension and other related pathologies.


Item Type:Article
Uncontrolled Keywords:defatted rice bran; antioxidant hydrolysates; antihypertensive activity; bioactive compounds; hypertensive rats
Subjects:Medical sciences > Medicine > Dietetics and Nutrition
Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Cardiovascular system
ID Code:67523
Deposited On:26 Aug 2021 10:45
Last Modified:06 Sep 2021 09:19

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