Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer



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Prieto Montero, Ruth and Prieto Castañeda, Alejandro and Katsumiti, Alberto and Cajaraville, Miren P. and Agarrabeitia, Antonia R. and Ortíz García, María Josefa and Martínez Martínez, Virginia (2021) Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer. International Journal of Molecular Sciences, 22 (6618). 23 p.. ISSN 1422-0067

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BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro.

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Received: 28 May 2021 / Accepted: 16 June 2021 / Published: 21 June 2021.

Uncontrolled Keywords:BODIPY-based photosensitizers; Functionalized silica nanoparticles; Folic acid; PEG; Photodynamic therapy; HeLa cells; (Photo) toxicity
Subjects:Sciences > Chemistry > Biochemistry
Sciences > Chemistry > Chemistry, Organic
Medical sciences > Medicine > Oncology
ID Code:67533
Deposited On:01 Dec 2021 12:40
Last Modified:01 Dec 2021 15:33

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