NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

Impacto

Downloads

Downloads per month over past year

Cores Esperón, Ángel and Piquero Martí, Marta and Villacampa Sanz, Mercedes and León Martínez, Rafael and Menéndez Ramos, Juan Carlos (2020) NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules, 10 (6). p. 904. ISSN 2218-273X

[thumbnail of biomolecules-10-00904-v2.pdf] PDF
Creative Commons Attribution.

10MB

Official URL: https://doi.org/10.3390/biom10060904




Abstract

NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.


Item Type:Article
Uncontrolled Keywords:NRF2–ARE pathway; neurodegenerative diseases; oxidative stress; KEAP1; NRF2 regulation
Subjects:Medical sciences > Pharmacy > Neurosciences
ID Code:67546
Deposited On:27 Aug 2021 11:39
Last Modified:27 Aug 2021 11:39

Origin of downloads

Repository Staff Only: item control page