The Value of OCT and OCTA as Potential Biomarkers for Preclinical Alzheimer's Disease: A Review Study



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López Cuenca, Inés and García Martín, Elena Salobrar and Elvira Hurtado, Lorena and Fernández Albarral, José Antonio and Sánchez Puebla, Lídia and Salazar Corral, Juan José and Ramirez Sebastian, Jose Manuel and Ramírez Sebastián, Ana Isabel and Hoz Montañana, María Rosa de (2021) The Value of OCT and OCTA as Potential Biomarkers for Preclinical Alzheimer's Disease: A Review Study. Life, 11 (712). 113 p.. ISSN 2075-1729

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Preclinical Alzheimer’s disease (AD) includes cognitively healthy subjects with at least one positive biomarker: reduction in cerebrospinal fluid Aβ42 or visualization of cerebral amyloidosis by positron emission tomography imaging. The use of these biomarkers is expensive, invasive, and not always possible. It has been shown that the retinal changes measured by optical coherence tomography (OCT) and OCT-angiography (OCTA) could be biomarkers of AD. Diagnosis in early stages before irreversible AD neurological damage takes place is important for the development of new therapeutic interventions. In this review, we summarize the findings of different published studies using OCT and OCTA in participants with preclinical AD. To date, there have been few studies on this topic and they are methodologically very dissimilar. Moreover, these include only two longitudinal studies. For these reasons, it would be interesting to unify the methodology, make the inclusion criteria more rigorous, and conduct longer longitudinal studies to assess the evolution of these subjects. If the results were consistent across repeated studies with the same methodology, this could provide us with insight into the value of the retinal changes observed by OCT/OCTA as potential reliable, cost-effective, and noninvasive biomarkers of preclinical AD.

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Received: 30 June 2021 / Accepted: 17 July 2021 / Published: 19 July 2021.

Uncontrolled Keywords:Alzheimer’s disease; Preclinical; Optical coherence tomography; Optical coherence tomography-angiography; Retina; Biomarker
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:67576
Deposited On:20 Dec 2021 13:23
Last Modified:29 Jun 2022 07:20

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