Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

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Gisbert Garzarán, Miguel and Vallet Regí, María (2021) Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates. Nanomaterials, 11 . p. 2222. ISSN 2079-4991

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Official URL: https://doi.org/10.3390/nano11092222




Abstract

Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reduc-tive species that are found within the cells, compared to bloodstream, which leads to the drug re-lease taking place only inside cells. This review is intended to provide a comprehensive overview of the most recent trends in the design of redox-responsive mesoporous silica nanoparticles. First, a general description of the biological rationale of this stimulus is presented. Then, the different types of gatekeepers that are able to open the pore entrances only upon application of reductive conditions will be introduced. In this sense, we will distinguish among those targeted and those non-targeted toward cancer cells. Finally, a new family of bridged silica nanoparticles able to degrade their struc-ture upon application of this type of stimulus will be presented.


Item Type:Article
Additional Information:

RESEARCH ID  S-2443-2016  (Miguel Gisbert Garzarán)
ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:mesoporous silica nanoparticles; redox-responsive; stimuli-responsive; drug delivery; cancer cell targeting; biodegradable nanoparticles; periodic mesoporous organosilica nanoparticles
Subjects:Sciences > Chemistry > Materials
ID Code:67598
Deposited On:01 Sep 2021 09:26
Last Modified:01 Sep 2021 09:26

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