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Roquero Tenorio, Irene (2021) Descubrimiento de nuevas moléculas activas frente a Trypanosoma cruzi y Leishmania donovani. [Thesis]
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Abstract
La leishmaniasis visceral (VL) y la enfermedad de Chagas (CD) son enfermedades causadas porparásitos kinetoplástidos que afectan a millones de personas en el mundo, lo que conlleva un gran impacto en la salud humana. Debido a la eficacia limitada y a los efectos adversos asociados al uso de los tratamientos actuales, existe una necesidad urgente de desarrollar nuevas terapias, con mayor eficacia y mejor perfil de seguridad para lograr tratar estas enfermedades. Existen varias estrategias a la hora de identificar y optimizar nuevos tratamientos frente a Leishmania y Trypanosoma cruzi: el descubrimiento de nuevos fármacos mediante el screening de novo de librerías, las terapias en combinación, el desarrollo de nuevas formulaciones de principios activos ya conocidos, y el reposicionamiento terapéutico o drug repurposing...
Resumen (otros idiomas)
Visceral leishmaniasis (VL) and Chagas disease (CD), caused by kinetoplastid parasites, affectmillions of people worldwide and impart a heavy burden against human health. Due to thelimited efficacy and toxicity related effects of the existing treatments, there is an urgent needto develop novel therapies with superior efficacy and safety profiles to successfully treat thesediseases. There are several strategies available with the aim of finding novel therapies againstLeishmania and Trypanosoma cruzi: the discovery of novel molecules by de novo screening ofcompound libraries, combination therapies, the development of novel formulations for alreadyknown drugs, and drug repurposing.The main focus of this thesis is the strategy based on de novo screening of Calibr 150 000compound library against the parasites Leishmania donovani, as a causative agent of VL, andTrypanosoma cruzi, that causes CD. With this objective, a progression cascade was designed foreach parasite, starting with the higher throughput assays and establishing, later on, the mostrelevant biological assays as secondary assays...
| Item Type: | Thesis |
|---|---|
| Additional Information: | Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología y Parasitología, leída el 01-06-2021 |
| Directors: | Directors Cantizani Pérez, Juan |
| Uncontrolled Keywords: | Leishmaniosis |
| Palabras clave (otros idiomas): | Leishmaniosis |
| Subjects: | Medical sciences > Pharmacy > Microbiology |
| ID Code: | 67708 |
| Deposited On: | 08 Sep 2021 12:53 |
| Last Modified: | 08 Sep 2021 13:01 |
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