Clinical outcomes of combined Preserflo Microshunt implantation and cataract surgery in open-angle glaucoma patients

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Martínez de la Casa, Jose Maria and Sáenz Francés, Federico and Morales Fernández, Laura and Perucho González, Lucía and Méndez García, Carmen M. and Fernández Vidal, Ana M. and García Sáenz, Sofía and Sánchez Jean, Rubén and García Feijoo, Julián (2021) Clinical outcomes of combined Preserflo Microshunt implantation and cataract surgery in open-angle glaucoma patients. Scientific reports, 11 (15600). 8 p.. ISSN 2045-2322

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Official URL: https://doi.org/10.1038/s41598-021-95217-x




Abstract

To assess the effectiveness and safety of the Preserflo Microshunt (PMS) implantation combined with cataract surgery in open-angle glaucoma (OAG) patients. Retrospective, open-label study conducted on insufficiently controlled OAG patients, who underwent a PMS implant procedure with mitomycin-C 0.2%, either alone or in combination with cataract surgery, and were followed for at least 12 months. Success was defined as an intraocular pressure (IOP) ≤ 18 mmHg and a reduction of at least 20% without (complete) or with (qualified) hypotensive medication. Fifty-eight eyes were included in the study, 35 eyes underwent PMS alone and 23 underwent PMS + Phaco. In the overall study sample, mean IOP was significantly lowered from 21.5 ± 3.3 mmHg at baseline to 14.6 ± 3.5 mmHg at month 12 (p < 0.0001). The IOP was significantly reduced in both groups; p < 0.0001 each, respectively. Ocular hypotensive medication was significantly reduced (p < 0.0001) in both groups. No significant differences were observed in IOP lowering or medication reduction between groups. At month 12, 62.1% eyes were considered as complete success and 82.8% eyes as qualified success. The most common adverse events were device close-to-endothelium, conjunctival fibrosis, and wound leakage. PMS, either alone or in combination with phacoemulsification, may be considered as a valuable option for treating OAG patients.


Item Type:Article
Additional Information:

Received: 27 May 2021; Accepted: 22 July 2021; Published: 02 August 2021.

Uncontrolled Keywords:Cataracts; Mitomycin; Eye; Glaucoma; Endothelium; Success; Patients; Eye surgery; Fibrosis; Mitomycin C; Surgery
Subjects:Medical sciences > Medicine > Surgery
Medical sciences > Medicine > Ophtalmology
ID Code:67847
Deposited On:20 Dec 2021 14:15
Last Modified:20 Dec 2021 15:13

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