Proinflammatory cytokine profile differences between primary open angle and pseudoexfoliative glaucoma



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Vidal Villegas, Beatriz and Burgos Blasco, Bárbara and Santiago Alvarez, Jose Luis and Espino Paisán, Laura and Fernández Vigo, José Ignacio and Andrés Guerrero, Vanessa and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2021) Proinflammatory cytokine profile differences between primary open angle and pseudoexfoliative glaucoma. Ophthalmic Research . ISSN 0030-3747; 1423-0259 (e)

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Introduction: Few studies have investigated glaucoma biomarkers in aqueous humor and tear and have found elevations of proinflammatory cytokines in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). In this study we investigate differences in inflammatory cytokines between POAG and PXG patients to find specific disease biomarkers.
Methods: For this purpose, tear and aqueous humor samples of 14 eyes with POAG and 15 eyes with PXG undergoing cataract surgery were immunoassayed for 27 pro-inflammatory cytokines. The concentrations of cytokines in tear and aqueous humor and their association with clinical variables were analysed, correlated and compared between the groups.
Results: We found that the levels of three cytokines differed significantly in the aqueous humor of POAG and PXG patients: IL-12 and IL-13 were higher in the POAG group, while MCP-1(MCAF) was higher in the PXG group. The number of topical hypotensive medications was correlated with diminished levels of two cytokines (IL-7 and basic fibroblast growth factor) in aqueous humor in the POAG group and with diminished levels of IL-12 in tear in the PXG group.
Conclusion: We conclude that both POAG and PXG show elevated concentrations of proinflammatory cytokines in tear and aqueous humor that could be used as biomarkers for these types of glaucoma and that the concentrations in aqueous humor of three cytokines: IL-12, IL-13 and MCP-1(MCAF) could be used to differentiate POAG and PXG.

Item Type:Article
Additional Information:

Received: June 02, 2021; Accepted: September 13, 2021; Published online: October 18, 2021; Issue release date: February 2022

Uncontrolled Keywords:Glaucoma biomarkers; Proinflammatory cytokines; Primary open angle glaucoma,; Pseudoexfoliative glaucoma; Aqueous humor; Tear; Ocular hypotensive medication
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Medicine > Ophtalmology
ID Code:67935
Deposited On:15 Feb 2022 18:46
Last Modified:16 Feb 2022 11:43

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