MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial

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Ruiz Pomeda, Alicia and Pérez Sánchez, Belén and Valls Ferran, Isabel and Prieto Garrido, Francisco Luis and Gutiérrez Ortega, Ángel Ramón and Villa Collar, César (2018) MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. Graefe's Archive for Clinical and Experimental Ophthalmology, 256 (5). pp. 1011-1021. ISSN 0721-832X

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Official URL: https://doi.org/10.1007/s00417-018-3906-z




Abstract

Purpose: To compare myopia progression in children randomized to MiSight contact lenses (CLs) versus children corrected with single-vision spectacles (SV) over a 2-year period.
Methods: Subjects aged 8 to 12 with myopia (−0.75 to −4.00 D sphere) and astigmatism (< −1.00 D cylinder) were assigned to the lens study group (MiSight) or the control group (single vision). Measurements of visual acuity and subjective refraction were taken at 6-month intervals, and axial length, anterior chamber, corneal power, and cycloplegic autorefraction were measured at the baseline, 12-month, and 24-month visits.
Results: Eighty-nine subjects were recruited. Forty-fix children were assigned to the MiSight group, and 33 to the single-vision spectacle group. In total, 74 children completed the clinical trial, with the following parameters at the beginning of the study: n = 41 in the MiSight group (age: 11.01 ± 1.23 years, spherical equivalent: −2.16 ± 0.94 D, gender: male: 21, female: 20) and n = 33 in the single-vision group (age: 10.12 ± 1.38 years, spherical equivalent: −1.75 ± 0.94 D, gender: male: 12, female: 21). After 2 years of follow-up, myopia progressed slowly in the MiSight group compared to the control group (0.45 D vs 0.74 D, p < 0.001) and there was less axial elongation in the MiSight group compared to the single-vision group (0.28 mm vs 0.44 mm, p < 0.001). Therefore, use of MiSight CLs produced lower myopia progression (39.32%) and lower axial growth of the eye (36.04%) at 2 years compared to spectacle use.
Conclusions: MiSight contact lens wear reduces axial elongation and myopia progression in comparison to distance single-vision spectacles in children.
ClinicalTrials.gov Identifier: NCT01917110.


Item Type:Article
Additional Information:

Received: 14 September 2017 ;Revised: 5 December 2017; Accepted: 10 January 2018; Published online: 3 February 2018.

Uncontrolled Keywords:MiSight ; Myopia ; Contact lenses ; Axial length ; Children
Subjects:Medical sciences > Optics
Medical sciences > Optics > Optometry
ID Code:68008
Deposited On:15 Feb 2022 19:18
Last Modified:16 Feb 2022 11:49

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