In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with an Uncommon Crystal Structure



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Yao, Jingke and Lifante, José and Rodríguez Sevilla, Paloma and Fuente Fernández, Rosa María de la and Sanz Rodríguez, Francisco and Ortgies, Dirk H. and Gómez Calderón, Óscar and Melle Hernández, Sonia and Ximendes, Erving and Jaque García, Daniel and Marin, Riccardo (2021) In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with an Uncommon Crystal Structure. Small, 17 (42). art. -2103505. ISSN 1613-6810

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The implementation of in vivo fluorescence imaging as a reliable diagnostic imaging modality at the clinical level is still far from reality. Plenty of work remains ahead to provide medical practitioners with solid proof of the potential advantages of this imaging technique. To do so, one of the key objectives is to better the optical performance of dedicated contrast agents, thus improving the resolution and penetration depth achievable. This direction is followed here and the use of a novel AgInSe2 nanoparticle-based contrast agent (nanocapsule) is reported for fluorescence imaging. The use of an Ag2Se seeds-mediated synthesis method allows stabilizing an uncommon orthorhombic crystal structure, which endows the material with emission in the second biological window (1000–1400 nm), where deeper penetration in tissues is achieved. The nanocapsules, obtained via phospholipid-assisted encapsulation of the AgInSe2 nanoparticles, comply with the mandatory requisites for an imaging contrast agent—colloidal stability and negligible toxicity—and show superior brightness compared with widely used Ag2S nanoparticles. Imaging experiments point to the great potential of the novel AgInSe2-based nanocapsules for high-resolution, whole-body in vivo imaging. Their extended permanence time within blood vessels make them especially suitable for prolonged imaging of the cardiovascular system.

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Received: June 16, 2021 / First published: 23 September 2021.

Uncontrolled Keywords:Bioimaging; In vivo; Infrared; Selenides; Semiconductor nanoparticles
Subjects:Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine
Medical sciences > Medicine > Optics
ID Code:68013
Deposited On:15 Feb 2022 19:42
Last Modified:16 Feb 2022 12:06

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