Our Contributions to Applications of Mesoporous Silica Nanoparticles

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Vallet Regí, María (2021) Our Contributions to Applications of Mesoporous Silica Nanoparticles. Acta Biomaterialia . ISSN 1742-7061 (In Press)

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Official URL: https://doi.org/10.1016/j.actbio.2021.10.011




Abstract

Our contribution to mesoporous silica materials in the field of biomedicine are reported in this article. This perspective article represents our work in the basics of the material, preparingdifferent ranges of mesoporous silica nanoparticles with different diameters and with varied pore sizes. We demonstrated the high loading capacity of these materials. Additionally, the possibility of functionalizing both internal and external surface with different organic or inorganic moieties allowed the development of stimuli-responsive features which allowed a proper control on the administered dose. In addition, we have demonstrated that these carriers are not toxic, and we have also ensured that the load reaches its destination without affecting healthy tissues.
Statement of Significance: Advances on mesoporous silica materials in the field of biomedicine are herein reported. This perspective article represents our work on the
fundametals of the material, preparing different ranges of mesoporous silica nanoparticles with different diameters and with varied pore sizes. The high drug loading capacity of these materials is demonstrated. Moreover, the possibility of functionalizing both internal and external surface with different organic or inorganic moieties allowed the development of stimuli-responsive nanocarriers which allowed a proper control on the administered dose. In addition, we have demonstrated that these carriers are not toxic, and we have also ensured that the load reaches its target without affecting healthy tissues.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica materials, Nanoparticles, Drug delivery, Controlled release, Functionalization, Stimuli-responsive, Targeting, Biocompatibility, Biomedicine
Subjects:Sciences > Chemistry > Materials
ID Code:68230
Deposited On:15 Oct 2021 07:06
Last Modified:05 Apr 2022 08:47

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