Abnormal liver function test in patients infected with Coronavirus (SARS-CoV-2): a retrospective Single-Center Study from Spain



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Benedé Ubieto, Raquel and Estevez Vázquez, Olga and Flores-Perojo, Vicente and Macías-Rodríguez, Ricardo U. and Ruiz-Margáin, Astrid and Martinez Naves, Eduardo and Regueiro González-Barros, José Ramón and Avila, Matías A. and Trautwein, Christian and Bañares, Rafael and Bosch, J. and Cubero Palero, Francisco Javier and Nevzorova, Yulia A. (2021) Abnormal liver function test in patients infected with Coronavirus (SARS-CoV-2): a retrospective Single-Center Study from Spain. Journal of Clinical Medicine, 10 (5). pp. 2-18. ISSN Electronic: 2077-0383

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Official URL: https://doi.org/10.3390/jcm10051039


The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.

Item Type:Article
Uncontrolled Keywords:SARS-CoV-2; Liver injury; Pandemic; AST/ALT ratio; Ferritin
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Biology > Molecular biology
Medical sciences > Biology > Microbiology
ID Code:68265
Deposited On:18 Oct 2021 11:21
Last Modified:19 Oct 2021 08:29

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