Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections.

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Esteban, Jaime and Vallet Regí, María and Correa Aguilera, John Jairo (2021) Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections. Antibiotics, 10 . p. 1270. ISSN 2079-6382

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Official URL: https://doi.org/10.3390/antibiotics10101270




Abstract

Prosthetic joint infection (PJI) is the second most common cause of arthroplasty failure.Though infrequent, it is one of the most devastating complications since it is associated with great personal cost for the patient and a high economic burden for health systems. Due to the high number of patients that will eventually receive a prosthesis, PJI incidence is increasing exponentially. As these infections are provoked by microorganisms, mainly bacteria, and as such can develop a biofilm, which is in turn resistant to both antibiotics and the immune system, prevention is the ideal approach. However, conventional preventative strategies seem to have reached their limit. Novel prevention strategies fall within two broad categories: (1) antibiotic- and (2) heavy metal-based surface modifications of titanium alloy prostheses. This review examines research on the most relevant titanium alloy surface modifications that use antibiotics to locally prevent primary PJI.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:prosthetic joint infection; local prevention
Subjects:Sciences > Chemistry > Materials
ID Code:68291
Deposited On:19 Oct 2021 18:06
Last Modified:19 Oct 2021 18:12

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