Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes

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Pacheco Quito, Edisson Mauricio and Ruiz Caro, Roberto and Rubio, Juan and Tamayo, Aitana and Veiga Ochoa, María Dolores (2020) Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes. Marine Drugs, 18 (5). p. 249. ISSN 1660-3397

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Official URL: https://doi.org/10.3390/md18050249




Abstract

Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.


Item Type:Article
Uncontrolled Keywords:genital herpes; acyclovir controlled release; mucoadhesive vaginal tablets; marine polymers; iota-carrageenan; hydroxypropyl methylcellulose
Subjects:Medical sciences > Medicine > Communicable diseases
Medical sciences > Pharmacy > Molecular biology
Medical sciences > Pharmacy > Pharmacology
ID Code:68531
Deposited On:04 Nov 2021 08:53
Last Modified:04 Nov 2021 09:02

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