Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses



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Perez Carrasco, Maria Jesus and Carballo Álvarez, Jesús and Barbur, John L. and Puell Marín, María Cinta (2021) Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses. Translational vision science & technology, 10 (12). 12 p.. ISSN 2164-2591

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Purpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of the retina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-related layer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects.
Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants. Spectraldomain optical coherence tomography (SD-OCT) was used to measure retinal thicknesses. Relationships between foveal and parafoveal FMS and the retinal thickness in the corresponding region were examined after adjusting for confounding variables.
Results: Total macular and inner retinal layer (IRL) thicknesses in the parafoveal ring were significant predictors of photopic (P = 0.034) and mesopic (P = 0.034) parafoveal FMS, respectively. The superior peripapillary retinal nerve fiber layer (pRNFL) thickness was a contributing factor to the inferior parafoveal FMS (photopic: P = 0.006 and mesopic: P = 0.021) and the inferior pRNFL thickness was also a contributing factor to the superior parafoveal FMS (photopic: P < 0.001 and mesopic: P = 0.015).
Conclusions: The pRNFL thicknesses predict parafoveal FMS for both mesopic and photopic conditions in healthy eyes. Translational Relevance: Themeasurement of rapid flicker sensitivity in the parafoveal retina together with the pRNFL thickness profiles measured before the onset of disease, may provide a more sensitive biomarker for detecting loss of sensitivity caused by the earliest neurodegenerative changes in the eyes.

Item Type:Article
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Received: April 26, 2021; Accepted: September 13, 2021; Published: October 14, 2021.

Uncontrolled Keywords:Flicker sensitivity; Temporal contrast sensitivity; Retinal nerve fiber layer (RNFL); Optical coherence tomography (OCT); Retinal thickness
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Optometry
Medical sciences > Optics > Eyes anatomy
ID Code:68578
Deposited On:24 Feb 2022 11:52
Last Modified:24 Feb 2022 12:55

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