Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

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Sánchez Salcedo, Sandra and Malavasi, Gianluca and Salinas Sánchez, Antonio J. and Lusvardi, Gigliola and Rigamonti, Luca and Menabue, Ledi and Vallet Regí, María (2018) Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III). Materials, 11 (3). p. 367. ISSN 1996-1944

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Official URL: https://doi.org/10.3390/ma11030367




Abstract

Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.


Item Type:Article
Uncontrolled Keywords:gallium ions; mesoporous glasses; glass structure; in vitro bioactivity; antibacterial capability
Subjects:Medical sciences > Pharmacy > Pharmaceutical chemistry
ID Code:68815
Deposited On:19 Nov 2021 13:49
Last Modified:22 Nov 2021 08:35

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