Publication: Caracterización de pacientes perinatalmente infectados por VIH-1 con un inicio precoz del tratamiento antirretroviral
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2021-11-24
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Universidad Complutense de Madrid
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Abstract
Desde el inicio de la epidemia de la infección por el VIH-1, la transmisión vertical del virus de una madre infectada a su hijo se ha considerado un problema de salud pública de primera magnitud. A pesar del avance de las políticas y medidas de prevención de la transmisión vertical madre-hijo, se estima que anualmente 150,000 niños aún se infectan con VIH-1. El tratamiento antirretroviral precoz ha conseguido ser eficaz en la reducción de mortalidad y morbilidad, en restaurar la función del sistema inmunológico y conseguir una supresión viral duradera. Sin embargo, aún se desconoce cuánto de precoz ha de ser el inicio del TAR y los factores asociados a su eficacia en el descenso de carga viral en niños. Asimismo, el TAR por sí solo no es capaz de eliminar la infección debido a la incapacidad de acceso al reservorio viral, lugares donde permanece el virus, produciéndose una infección latente. Conocer los factores asociados a un reservorio bajo podría arrojar luz sobre la remisión del VIH-1 en pacientes pediátricos...
Since the beginning of the epidemic, HIV mother-to-child transmission has been recognised as a major public health issue. Despite the great efforts done to reduce HIV infection among children, in 2015, more than 150,000 children became infected with HIV. Early combination antiretroviral therapy (ART) initiation in vertically infected infants with HIV has had a major impact on clinical outcomes reducing morbidity and mortality. Moreover, early initiation of ART leads to a significantly smaller reservoir size and a better immune reconstitution. However, definitions of early vary a great deal and literature reporting on ART initiation in the first year of life rarely reports on outcomes when treatment is initiated in the neonatal period. Also, there is limited information about factors associated with the rapid decline of the viral load in infants...
Since the beginning of the epidemic, HIV mother-to-child transmission has been recognised as a major public health issue. Despite the great efforts done to reduce HIV infection among children, in 2015, more than 150,000 children became infected with HIV. Early combination antiretroviral therapy (ART) initiation in vertically infected infants with HIV has had a major impact on clinical outcomes reducing morbidity and mortality. Moreover, early initiation of ART leads to a significantly smaller reservoir size and a better immune reconstitution. However, definitions of early vary a great deal and literature reporting on ART initiation in the first year of life rarely reports on outcomes when treatment is initiated in the neonatal period. Also, there is limited information about factors associated with the rapid decline of the viral load in infants...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 14-07-2021