Publication: Formulaciones sólidas mucoadhesivas vaginales basadas en polímeros naturales para liberación sostenida de microbicidas destinadas a la prevención de la transmisón sexual del VIH
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2021-11-26
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Universidad Complutense de Madrid
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Abstract
En ausencia de una vacuna eficaz frente al virus de la inmunodeficiencia humana (VIH), el Programa Conjunto de las Naciones Unidas sobre el VIH/SIDA (ONUSIDA) recomienda el desarrollo productos estables, seguros, efectivos y aceptables que puedan reducir con éxito la transmisión sexual de este virus. La profilaxis preexposición mediante formulaciones de administración vaginal puede ser útil para este objetivo, ya que aporta a las mujeres una opción de autoprotección sin necesidad del consentimiento de la pareja sexual. Sin embargo, ensayos clínicos con microbicidas de administración vaginal han fallado en su propósito debido a una baja adherencia al tratamiento al ser necesaria una administración diaria. En el presente trabajo de tesis se propone el desarrollo y la evaluación de formulaciones vaginales basadas en polímeros naturales para la liberación sostenida de fármacos antirretrovirales...
In the absence of an effective vaccine against the human immunodeficiency virus (HIV), the Joint United Nations Program on HIV/AIDS (UNAIDS) recommends the development of stable, safe, effective and acceptable products that can successfully reduce the HIV sexual transmission. The pre-exposure prophylaxis through vaginal administered formulations can be useful for this purpose, since it provides women with an option of self-protection without the need of permission of the sexual partner. However, most clinical trials with microbicides for vaginal administration have failed in their purpose due to low adherence to treatments caused by the need of daily administration. This thesis purposes the development and characterization of vaginal formulations based on natural polymers for the sustained release of antiretroviral drugs...
In the absence of an effective vaccine against the human immunodeficiency virus (HIV), the Joint United Nations Program on HIV/AIDS (UNAIDS) recommends the development of stable, safe, effective and acceptable products that can successfully reduce the HIV sexual transmission. The pre-exposure prophylaxis through vaginal administered formulations can be useful for this purpose, since it provides women with an option of self-protection without the need of permission of the sexual partner. However, most clinical trials with microbicides for vaginal administration have failed in their purpose due to low adherence to treatments caused by the need of daily administration. This thesis purposes the development and characterization of vaginal formulations based on natural polymers for the sustained release of antiretroviral drugs...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 01-10-2021