Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

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Legarda Ceballos, Ana L. and del Olmo, Esther and López-Abán, Julio and Escarcena, Ricardo and Bustos, Luis A. and Fonseca Berzal, Cristina Rosa and Gómez Barrio, Alicia and Dib, Juan and San Feliciano, Arturo and Muro, Antonio (2015) Trypanocidal Activity of Long Chain Diamines and Aminoalcohols. Molecules, 20 (6). pp. 11554-11568. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules200611554




Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.


Item Type:Article
Uncontrolled Keywords:aminoalcohols; diamines; Trypanosoma cruzi; epimastigotes; amastigotes; cytotoxicity
Subjects:Medical sciences > Pharmacy > Parasitology
ID Code:68988
Deposited On:02 Dec 2021 15:27
Last Modified:20 Dec 2021 08:52

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